Quick verdict
Open WebUI is chat-first; AnythingLLM is workspace/document-first.
Use Open WebUI when you want a polished self-hosted chat interface over local models. Use AnythingLLM when document chat, workspace organization, and knowledge assistant workflows are the center of the product.
Pick Open WebUI for chat UX
It fits teams that mainly want a familiar private chat interface.
Pick AnythingLLM for knowledge workflows
It fits teams that need documents, sources, and workspaces around assistant usage.
